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Rationally Designed DNA Nanostructures for Drug Delivery.
Fan Xu1, Qing Xia1, Pengfei Wang1
1Institute of Molecular Medicine, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, State Key Laboratory of Oncogenes and Related Genes, Department of Oncology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Frontiers in Chemistry
|November 16, 2020
Summary
DNA nanostructures offer precise material engineering for potent drug delivery. This review covers their construction, overcoming biological barriers, and future clinical applications.
Area of Science:
- Biotechnology
- Nanotechnology
- Materials Science
Background:
- DNA's unique sequence-specific interactions enable precise material engineering.
- Self-assembled DNA nanostructures show significant in vitro and in vivo drug delivery efficiency.
- Integration with functional moieties like ligands and nanoparticles enhances DNA nanostructure performance.
Purpose of the Study:
- To review strategies for constructing DNA nanostructures.
- To summarize biological barriers in DNA nanostructure-based drug delivery.
- To discuss solutions and future opportunities for clinical applications.
Main Methods:
- Review of existing literature on DNA nanostructure construction.
- Analysis of biological barriers impacting drug delivery systems.
- Exploration of conjugation techniques for functionalization.
Main Results:
- DNA nanostructures can be precisely engineered for controlled material properties.
- Various strategies exist to overcome biological barriers for enhanced drug delivery.
- Functionalization significantly improves the efficacy and targeting of DNA nanostructures.
Conclusions:
- DNA nanostructures hold great promise for advanced drug delivery systems.
- Overcoming biological barriers is crucial for translating DNA nanostructures to clinical settings.
- Further research is needed to address challenges and realize the full potential of DNA nanostructures in medicine.
