Related Experiment Video
Updated: Nov 30, 2025
09:50
Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons
Published on: April 20, 2018
10.3K
How Do Cortical Excitatory Neurons Terminate Their Migration at the Right Place? Critical Roles of Environmental
Yumiko Hatanaka1, Tatsumi Hirata2,3
1Graduate School of Frontier Biosciences, Osaka University, Suita, Japan.
Frontiers in Cell and Developmental Biology
|November 16, 2020
Summary
Neuronal migration termination in brain development relies on interactions between migrating neurons and their environment. Environmental cues and changes in cell adhesion guide neurons to their final positions, ensuring proper brain structure.
Area of Science:
- Neuroscience
- Developmental Biology
- Cell Biology
Background:
- Neuronal migration is fundamental to brain development, establishing functional neural circuits.
- Proper termination of neuronal migration is critical for correct brain architecture and function.
- Understanding the environmental interactions guiding migration termination is key.
Purpose of the Study:
- To review the migration behavior of cortical excitatory neurons.
- To identify environmental factors essential for migration termination.
- To elucidate the role of cell adhesion dynamics in this process.
Main Methods:
- Review of existing literature on neuronal migration.
- Analysis of morphological and behavioral changes during migration.
- Synthesis of data on environmental interactions and cell adhesion.
Main Results:
- Cortical excitatory neurons exhibit distinct morphological and behavioral changes during migration.
- Extracellular matrix proteins, Cajal-Retzius cells, radial glial cells, and neighboring neurons are crucial environmental cues.
- Sequential changes in neuronal and environmental adhesiveness facilitate migration termination.
Conclusions:
- Proper migration termination requires a complex interplay between migrating neurons and their environment.
- Dynamic changes in cell adhesion are critical for neurons to reach, detach, and integrate into final positions.
- This process ensures the establishment of stable laminar structures in the developing brain.
Related Concept Videos
01:19The Role of Ion Channels in Neuronal Computation
3.5K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.5K
01:21Chemotaxis and Direction of Cell Migration
4.1K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
4.1K
01:09Synaptic Signaling
6.2K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
6.2K
01:12Synaptic Signaling
78.4K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
78.4K
01:09Cell Migration
17.9K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
17.9K