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Protein Palmitoylation in Leukocyte Signaling and Function
Xiaoyuan Yang1, Victor Chatterjee1, Yonggang Ma1
1Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Frontiers in Cell and Developmental Biology
|November 16, 2020
Summary
Palmitoylation, a reversible protein modification, is crucial for leukocyte functions like adhesion and signaling. This review details palmitoylated proteins in leukocytes and their functional roles.
Area of Science:
- Immunology
- Molecular Biology
- Biochemistry
Background:
- Palmitoylation is a dynamic post-translational modification (PTM) involving the attachment of palmitic acid to cysteine residues.
- This process is regulated by palmitoyl acyltransferases (PAT-DHHCs) and thioesterases, allowing reversible control over protein function.
- Palmitoylation influences protein conformation, stability, interactions, and localization to lipid rafts, essential for many cell surface receptors and signaling proteins.
Purpose of the Study:
- To review recent findings on palmitoylated proteins in leukocytes.
- To explore the functional significance of palmitoylation in various leukocyte activities.
Main Methods:
- Literature review of studies investigating palmitoylation in leukocytes.
- Analysis of reported palmitoylated leukocyte proteins and their functions.
Main Results:
- Numerous leukocyte proteins, including receptors, adhesion molecules, and signaling kinases, are palmitoylated.
- Palmitoylation impacts key leukocyte functions such as adhesion, transmigration, chemotaxis, phagocytosis, and cytokine production.
Conclusions:
- Palmitoylation is a critical regulatory mechanism for diverse leukocyte functions.
- Understanding palmitoylation in leukocytes offers insights into immune cell செயல்பாடுகள் and potential therapeutic targets.
Keywords:
DHHC palmitoyl transferasesleukocyte behaviorsleukocyte function/activationpalmitoylationprotein functionsignal transductionMore Related Videos
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