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B-cell chronic lymphocytic leukaemia with aberrant expression of CD8 antigen
A Porwit1, L Borgonovo, E Osby
1Division of Haematology, Karolinska Hospital, Stockholm, Sweden.
European Journal of Haematology
|October 1, 1987
Abstract:
The monoclonal antibodies against CD8 (T suppressor/cytotoxic) antigen (Leu2/OKT8) were found to bind to leukaemic lymphocytes from a patient with chronic lymphocytic leukaemia. The cells also had an unusual type of rod-like cytoplasmic immunoglobulin of IgM/lambda type as seen by light, fluorescence and electron microscopy, and displayed several antigens characteristic for B lymphocytes. Gene rearrangement analysis showed rearrangement of mu heavy chain gene. In spite of an expression of CD8 antigen, T-cell receptor genes were not rearranged.