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Multi-species Conserved Sequences

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale studies have provided new insights into the evolutionary relationship between organisms.
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Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...

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Conserved Binding Sites

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
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Updated: Nov 30, 2025

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Published on: August 24, 2017

dbCNS: A New Database for Conserved Noncoding Sequences.

Jun Inoue^1,2, Naruya Saitou^1,3

¹Population Genetics Laboratory, Department of Genomics and Evolutionary Biology, National Institute of Genetics, Mishima, Japan.

Molecular Biology and Evolution

|November 16, 2020

Summary

This summary is machine-generated.

We created dbCNS, a new database for conserved noncoding sequences (CNSs) across vertebrate genomes. This resource aids in understanding gene regulation, morphological changes, and genetic diseases linked to CNSs.

Keywords:

cis-regulatory elements conserved noncoding sequences dbCNS single-nucleotide polymorphisms vertebrates

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Area of Science:

Genomics
Bioinformatics
Evolutionary Biology

Background:

Conserved noncoding sequences (CNSs) are crucial for gene expression regulation in eukaryotes.
Mutations within CNSs are implicated in morphological alterations and genetic disorders.
Previous efforts identified numerous CNSs, particularly in primate genomes.

Purpose of the Study:

To introduce dbCNS, a novel database for conserved noncoding sequences.
To provide a powerful pipeline for identifying CNSs in vertebrate genomes.
To link CNSs to potential roles in morphological changes and genetic diseases.

Main Methods:

Development of a precise CNS identification pipeline for multiple vertebrate genomes.
Integration of approximately 6.9 million CNSs from diverse vertebrate species.
Incorporation of genome sequences from 161 species and links to dbSNP for human CNSs.

Main Results:

dbCNS enables efficient extraction of CNSs near specific genes via keyword searches.
The database supports phylogenetic analysis and evaluation of CNS evolution (modifications, acquisitions, losses).
Fast analysis (30s for 38 gnathostome genomes) and comparison with other CNS identification tools are supported.

Conclusions:

dbCNS serves as a valuable resource for studying conserved noncoding sequences and their functions.
The database facilitates research connecting genetic variations in CNSs to phenotypic outcomes and diseases.
dbCNS enhances the analysis of genome-scale data for conserved noncoding elements.