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Related Concept Videos

Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

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Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Updated: Nov 30, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Recent developments in dermoscopy for dermatology.

Xi Chen1, Quansheng Lu2, Can Chen3

  • 1Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Journal of Cosmetic Dermatology
|November 16, 2020
PubMed
Summary
This summary is machine-generated.

Dermoscopy, a key tool in dermatology, allows in vivo examination of skin structures. This review covers the latest advancements in various dermoscopy techniques for improved diagnosis.

Keywords:
computer-aided diagnosisdermoscopydigital dermoscopyvideodermoscopy

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Area of Science:

  • Dermatology
  • Medical Imaging
  • Histopathology

Background:

  • Dermoscopy bridges clinical observation and histopathology for in vivo skin microstructure examination.
  • Technological advancements include polarized light, videodermoscopy, and digital dermoscopy.
  • Applications span pigmented lesions, general dermatology, and appendage/infectious/inflammatory conditions.

Purpose of the Study:

  • To review the latest developments in dermoscopy.
  • Focus on handheld, videodermoscopy, fluorescence-advanced videodermatoscopy, polarized transilluminating dermoscopy, and digital dermoscopy.

Main Methods:

  • Literature search of PubMed, Embase, Web of Science, and Cochrane Library.
  • Included reviews, case reports, and observational studies on dermoscopy.

Main Results:

  • An updated review of dermoscopy based on published literature was provided.

Conclusions:

  • Dermoscopy is an essential diagnostic tool in dermatology.
  • Further development of dermoscopy is anticipated.