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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Controlling Geminiviruses before Transmission: Prospects.

Muhammad Salman Mubarik1, Sultan Habibullah Khan1,2, Aftab Ahmad2,3

  • 1Centre for Agricultural Biochemistry and Biotechnology (CABB), University of Agriculture, Faisalabad 38040, Pakistan.

Plants (Basel, Switzerland)
|November 17, 2020
PubMed
Summary

Manipulating bacterial endosymbionts in whiteflies can block Geminivirus transmission, offering a novel strategy for controlling devastating crop plant diseases and improving agricultural sustainability.

Keywords:
geminivirusesgenetic engineeringgenetically modified (GM) cropsvirus transmissionwhitefly

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Area of Science:

  • Plant pathology
  • Insect vector biology
  • Microbial symbiosis

Background:

  • Geminiviruses, transmitted by whiteflies (Bemisia tabaci), cause significant crop diseases globally.
  • Bacterial endosymbionts within insect vectors play a crucial role in virus transmission.
  • Molecular chaperonins of endosymbionts are implicated in binding virus particles.

Purpose of the Study:

  • To explore the potential of manipulating bacterial endosymbionts to obstruct Geminivirus transmission.
  • To investigate novel strategies for controlling viral diseases by targeting insect-vector-microbe interactions.

Main Methods:

  • Focuses on the conceptual framework of disrupting virus transmission by altering endosymbiont biology.
  • Highlights the importance of studying the intricate web of interactions between viruses, insects, and their microbial partners.

Main Results:

  • Identifying molecular chaperonins as key players in Geminivirus transmission by whiteflies.
  • Demonstrating that manipulating endosymbionts can disrupt virus-insect-microbe interactions.

Conclusions:

  • Targeting bacterial endosymbionts presents a promising new avenue for managing Geminivirus diseases.
  • Exploiting the insect vector's microbial community offers a sustainable approach to crop protection.