Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.8K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.6K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.6K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

3.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.7K
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

2.0K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.0K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

3.3K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.3K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.9K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stoichiometric Characteristics of Carbon, Nitrogen, and Phosphorous and Allometric Nitrogen-Phosphorous Relationships During the Organ-to-Forest Floor Material Transformation in Representative Forest Tree Species on the Southern Slope of the Qilian Mountains.

Biology·2026
Same author

<i>Arabidopsis thaliana Xylem Cysteine Protease 1 Gene</i> Regulates Xylem Bridge Reconnection and Delayed Incompatibility in <i>Arabidopsis</i>/<i>Nicotiana</i> Interfamilial Grafts.

Plants (Basel, Switzerland)·2026
Same author

Conditional knockout of membrane-type I matrix metalloproteinase in smooth muscle cells of adult mice alleviates atherosclerosis without affecting basic cardiovascular function.

Clinical and translational medicine·2026
Same author

Effects of crutch-assisted walking on pain, gait, and hip function in early and middle-stage osteonecrosis: a randomized trial.

Journal of orthopaedic translation·2026
Same author

Serum SOS1 as a prognostic biomarker and therapeutic target for progressive liver disease.

iScience·2026
Same author

Response Changes in Biological Soil Crusts (BSCs) to Different Sand-Fixing Plantations in Alpine Sandy Land.

Biology·2026

Related Experiment Video

Updated: Nov 30, 2025

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
10:37

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice

Published on: January 16, 2015

13.5K

Correlation between sestrin2 expression and airway remodeling in COPD.

Da-Wei Zhang1,2, Yuan-Yuan Wei1,2, Shuang Ji1,2

  • 1Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, People's Republic of China.

BMC Pulmonary Medicine
|November 17, 2020
PubMed
Summary

Increased sestrin2 expression correlates with airway remodeling in chronic obstructive pulmonary disease (COPD). Sestrin2 may serve as a novel biomarker for detecting airway remodeling in COPD patients.

Keywords:
Airway remodelingCOPDMatrix metalloproteinase 9Quantitative computed tomographySestrin2

More Related Videos

Author Spotlight: Development and Characterization of an In Vitro Model to Study Chronic Cigarette Smoke Exposure and Its Impact on Airway Epithelial Cells in COPD Research
09:07

Author Spotlight: Development and Characterization of an In Vitro Model to Study Chronic Cigarette Smoke Exposure and Its Impact on Airway Epithelial Cells in COPD Research

Published on: July 12, 2024

1.6K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

643

Related Experiment Videos

Last Updated: Nov 30, 2025

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
10:37

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice

Published on: January 16, 2015

13.5K
Author Spotlight: Development and Characterization of an In Vitro Model to Study Chronic Cigarette Smoke Exposure and Its Impact on Airway Epithelial Cells in COPD Research
09:07

Author Spotlight: Development and Characterization of an In Vitro Model to Study Chronic Cigarette Smoke Exposure and Its Impact on Airway Epithelial Cells in COPD Research

Published on: July 12, 2024

1.6K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

643

Area of Science:

  • Pulmonary Medicine
  • Biochemistry
  • Medical Imaging

Background:

  • Airway remodeling is a key feature of chronic obstructive pulmonary disease (COPD), linked to oxidative stress.
  • Sestrin2, an antioxidant protein, has emerged as a potential factor in this process.
  • The relationship between sestrin2 and COPD airway remodeling requires further investigation.

Purpose of the Study:

  • To investigate the correlation between sestrin2 expression and airway remodeling in COPD patients.
  • To evaluate sestrin2 as a potential biomarker for airway remodeling in COPD.

Main Methods:

  • 124 subjects (62 COPD, 62 controls) were analyzed.
  • Airway tissue and serum samples were assessed for sestrin2 and MMP9 expression/concentration using immunohistochemistry and ELISA.
  • Computed tomography (CT) scans were used to measure airway parameters and evaluate remodeling.

Main Results:

  • COPD patients exhibited pathological airway remodeling, increased sestrin2 and MMP9 expression in tissues and serum, and elevated airway parameters on CT.
  • Serum sestrin2 concentration positively correlated with serum MMP9 and CT-measured airway parameters.
  • These findings indicate a significant association between sestrin2 and airway remodeling in COPD.

Conclusions:

  • Elevated sestrin2 expression is linked to airway remodeling in COPD.
  • Sestrin2 shows promise as a novel biomarker for airway remodeling in COPD patients.