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Updated: Nov 30, 2025

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Rethinking organoid technology through bioengineering.

Elena Garreta1,2, Roger D Kamm3, Susana M Chuva de Sousa Lopes4

  • 1Pluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.

Nature Materials
|November 17, 2020
PubMed
Summary

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This summary is machine-generated.

Bioengineering advances control over human pluripotent stem cell (hPSC) organoid differentiation. This integration enhances organoid functionality for applications in developmental biology and personalized medicine.

Area of Science:

  • Stem cell biology
  • Bioengineering
  • Developmental biology

Background:

  • Human pluripotent stem cells (hPSCs) differentiation protocols have advanced.
  • Organoid derivation is a key step, often using 3D culture and self-organization.
  • Current methods offer limited control over external inputs.

Purpose of the Study:

  • To review achievements and challenges in integrating hPSC organoid differentiation with bioengineering.
  • To highlight the need for engineering solutions to control organoid self-organization and function.
  • To guide future research in generating higher-grade hPSC organoids.

Main Methods:

  • Review of current literature on hPSC differentiation and organoid development.
  • Analysis of bioengineering approaches for controlled stimuli in organoid culture.

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  • Discussion of ethical considerations in hPSC-derived organoid research.

    • Main Results:

    • Bioengineering offers controlled stimuli for hPSC organoid differentiation.
    • Engineering solutions can overcome limitations in self-organization and functionality.
    • Integration of hPSC organoids, bioengineering, and ethics is crucial.

    Conclusions:

    • Controlled bioengineering is essential for advancing hPSC organoid technology.
    • Improved organoids have potential in developmental biology, drug screening, disease modeling, and personalized medicine.
    • Addressing ethical aspects alongside technological advancements is vital.