Efficacy of multi-electrode linear irreversible electroporation.
Thomas J Buist1,2, Marijn H A Groen2, Fred H M Wittkampf2
1Department of Cardiology, Isala Hospital, Heart Centre, Dr Van Heesweg 2, 8025 AB Zwolle, The Netherlands.
Summary
Linear multi-electrode irreversible electroporation (IRE) effectively creates deep, continuous lesions in epicardial tissue. This study demonstrates IRE
Area of Science:
- Cardiovascular Research
- Biomedical Engineering
- Electrophysiology
Background:
- Irreversible electroporation (IRE) is an emerging ablation technology.
- Epicardial applications require precise electrode placement and energy delivery.
- Evaluating novel electrode configurations for IRE is crucial for clinical translation.
Purpose of the Study:
- To assess the efficacy of linear multi-electrode irreversible electroporation (IRE) for epicardial ablation.
- To determine lesion characteristics (depth, width, continuity) created by IRE in a porcine model.
- To evaluate the impact of different energy levels (50 J vs. 100 J) on lesion formation.
Main Methods:
- A porcine model (6 pigs) was used for epicardial IRE.
- A linear seven-polar electrode catheter was applied to the epicardium.
- Single IRE applications (50 J and 100 J) were delivered, followed by histological analysis after 3 weeks.
Main Results:
- Both 50 J and 100 J IRE applications created lesions with significant depth and width.
- 100 J applications resulted in significantly deeper (5.5 mm vs. 3.2 mm) and wider (5.4 mm vs. 3.9 mm) lesions compared to 50 J.
- Longitudinal analysis confirmed continuous lesions for 100 J applications.
Conclusions:
- Linear multi-electrode IRE is effective for creating continuous, deep epicardial lesions.
- Higher energy levels (100 J) yield larger lesion volumes.
- This technique shows promise for future cardiac ablation strategies.
