Related Experiment Video
Updated: Nov 30, 2025
Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
Age-Related Changes in the Association Between Traumatic Brain Injury and Dementia in Older Men and Women
Louis Jacob1, Philippe Azouvi, Karel Kostev
1Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France, and Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Barcelona, Spain (Dr Jacob); Department of Physical Medicine and Rehabilitation, Raymond Poincaré Hospital, Garches, France, and EA4047, UFR des Sciences de la Santé, Université Versailles Saint-Quentin-en-Yvelines, "Handi-Resp," Simone Veil, France (Dr Azouvi); and Epidemiology, IQVIA, Frankfurt, Germany (Dr Kostev).
Objective:
To investigate age-related changes in the association between traumatic brain injury (TBI) and dementia in older men and women separately.
Setting:
A total of 243 general practices in the UK.
Participants:
This study included 4760 patients who received a first TBI diagnosis between 1995 and 2010 (index date), and 4760 patients without TBI who were matched to those with TBI by age, sex, index year, Charlson Comorbidity Index, alcohol dependence, and physician (index date: a randomly selected visit date).
Design:
Retrospective cohort study.
Main Measures:
Incidence of dementia in the decade following index date.
Results:
Within 10 years of index date, 8.8% of men with TBI and 4.8% of those without TBI were diagnosed with dementia, while the respective figures were 9.0% and 6.7% in women (P values < .01). There was a significant association between TBI and dementia in men (hazard ratio [HR] = 2.29, 95% confidence interval [CI]: 1.64-3.19) and in women (HR = 1.33, 95% CI: 1.07-1.64). Furthermore, the association between TBI and dementia was significant in men aged 60 to 70 (HR = 2.51, 95% CI: 1.27-4.96) and 71 to 80 years (HR = 3.00, 95% CI: 1.82-4.93), whereas the relationship was only significant and potentially unreliable in women aged 81 to 90 years (HR = 1.49, 95% CI: 1.03-2.14).
Conclusions:
The age-related relationship between TBI and dementia differed between men and women. More research of a prospective nature and including behavioral data is needed to better understand these differences.
More Related Videos
05:01Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
Published on: August 16, 2019
08:27Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
Published on: April 11, 2025
Related Concept Videos
01:30Dementia
The progression of dementia is generally gradual....
01:30Cognitive Development During Adulthood
01:26Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
01:27Pharmacodynamics in Geriatric Patients: Effects of Age