Coassembly of C₁₃-Dipeptides: Gelations from Solutions and Precipitations

C₁₃-dipeptides that did not gel on their own were found to form hydrogels when combined with mixtures (coassembly). At pH = 4.6, by mixing negatively charged C₁₃-WD (C₁₃-WD^2- and/or C₁₃-WD^-) with C₁₃-KW or C₁₃-YK, where the side chain of K carried positive charge, two composite hydrogels with different mechanical properties were formed. The gels exhibited various fiber structures that would account for their individual functionalities. According to molecular dynamics computer simulations, the composite systems formed spherical micelles through hydrophobic interactions that further aggregate to form gels through electrostatic interactions. The electrostatic repulsions between C₁₃-WD molecules were interfered by insertions of C₁₃-KW or C₁₃-YK molecules, which result in gel formation in the composite systems. The results of computer simulations well explained the experimental observations, which provided new insights into the design and selection strategies for peptide gelators.