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Non-Invasive Real-Time Monitoring of Glucose Level Using Novel Microwave Biosensor Based on Triple-Pole CSRR.

Ala Eldin Omer, George Shaker, Safieddin Safavi-Naeini

    IEEE Transactions on Biomedical Circuits and Systems
    |November 17, 2020
    PubMed
    Summary

    This study presents a novel microwave biosensor for non-invasive glucose monitoring. The triple-pole complementary split ring resonator (TP-CSRR) sensor demonstrates high sensitivity for real-time blood glucose level detection.

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    Area of Science:

    • Biomedical Engineering
    • Microwave Engineering
    • Sensor Technology

    Background:

    • Planar microwave sensors offer non-invasive dielectric probing of biological tissues due to cost-effectiveness, simple fabrication, and minimal health risks.
    • Accurate, real-time glucose monitoring is crucial for managing diabetes and preventing complications.

    Purpose of the Study:

    • To develop and measure a novel microwave biosensor for non-invasive, real-time monitoring of glucose levels.
    • To assess the sensor's capability in detecting glucose variations in blood-mimicking solutions.

    Main Methods:

    • A novel microwave biosensor design integrating a rectangular plexiglass channel on a triple-pole complementary split ring resonator (TP-CSRR).
    • Fabrication using PCB on an FR4 dielectric substrate, operating in the 1-6 GHz range.
    • Excitation via a coupled microstrip transmission line and monitoring of harmonic reflection and transmission resonances.

    Main Results:

    • The TP-CSRR sensor successfully monitored glucose level changes in blood-mimicking solutions (70-120 mg/dL).
    • Demonstrated capability to detect small variations in dielectric properties of blood samples responsive to electromagnetic fields.
    • Achieved a sensitivity of 6.2 dB/(mg/ml), outperforming conventional single-pole sensors in resonance amplitude resolution.

    Conclusions:

    • The developed TP-CSRR microwave biosensor is effective for non-invasive, real-time glucose level monitoring.
    • The sensor exhibits superior sensitivity and resolution compared to existing microwave biosensor designs.
    • This technology holds promise for improved diabetes management through accurate glucose level tracking.