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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
Published on: February 16, 2015
18.4K
The Problem of Apoptotic Processes Reversibility
I I Zakharov1, M A Savitskaya1, G E Onishchenko2
1Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia.
Biochemistry. Biokhimiia
|November 17, 2020
Summary
Apoptosis, a form of cell death, is reversible. Key apoptotic events can occur without cell death, and cells can recover through anastasis, impacting disease and treatment.
Area of Science:
- Cell Biology
- Molecular Biology
- Pathology
Background:
- Apoptosis, or programmed cell death, was long considered an irreversible process.
- Recent findings challenge this notion, suggesting key apoptotic events are reversible.
Purpose of the Study:
- To review the reversibility of apoptosis and the phenomenon of anastasis (cell recovery after apoptosis).
- To explore the implications of apoptotic reversibility for normal cell function, disease, and therapeutic strategies.
Main Methods:
- Literature review of studies on apoptosis and cell recovery.
- Analysis of molecular and cellular mechanisms underlying apoptotic reversibility.
Main Results:
- Key apoptotic events like phosphatidylserine externalization and caspase activation are not always terminal.
- Cells can undergo anastasis, recovering from apoptotic stimuli upon their removal.
- This reversibility can promote the survival of damaged or cancerous cells.
Conclusions:
- Understanding apoptotic reversibility and anastasis is crucial for developing new therapeutic strategies.
- This knowledge can improve treatments for cancer and neurodegenerative diseases by modulating cell survival and death pathways.
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