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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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Molecular Mechanisms and Function of the p53 Protein Family Member - p73

G Melino1

  • 1Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, 00133, Italy. melino@uniroma2.it.

Biochemistry. Biokhimiia
|November 17, 2020
PubMed

Insights

The p73 protein family, identified after p53, plays a key role in cancer and neuro-development. Studies using knockout mice models have elucidated p73

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • p53's critical role in cancer was established over 20 years ago.
  • p63 and p73, members of the same protein family, were identified subsequently.
  • Significant research has accumulated on p63 and p73, including their interrelations.

Purpose of the Study:

  • To recapitulate the major milestones in understanding the biological role of p73.
  • To highlight the significance of TP73 in various biological processes.

Main Methods:

  • Utilizing four distinct p73 knockout mouse models with specific gene deletions.
  • Conducting expression studies in cancer.
  • Compiling a body of molecular studies.

Main Results:

  • Elucidation of the biological role of p73 through knockout mouse models.
  • Establishment of TP73's major role in cancer.
  • Identification of TP73's involvement in neuro-development, ciliogenesis, and metabolism.

Conclusions:

  • TP73 is a crucial gene with significant implications in cancer and neuro-development.
  • The study provides a comprehensive overview of TP73 research milestones.
  • Further understanding of p73's functions is essential.

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