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Occupational chemicals and pancreatitis: a link?
J M Braganza1, J E Jolley, W R Lee
1University Department of Gastroenterology, Manchester Royal Infirmary, U.K.
Summary
Occupational exposure to certain chemicals like diesel fumes and solvents may trigger idiopathic pancreatitis. Symptoms in some patients resolved upon removal from these workplace exposures.
Area of Science:
- Occupational Medicine
- Gastroenterology
- Toxicology
Background:
- Idiopathic pancreatitis is a growing concern.
- Cytochromes P450 are found to be induced in most patients with pancreatitis.
- This suggests environmental factors may play a role.
Purpose of the Study:
- To investigate potential enzyme inducers in the work environments of patients with idiopathic pancreatitis.
- To explore the link between occupational exposures and both idiopathic and alcohol-related pancreatitis.
Main Methods:
- The study examined 19 patients diagnosed with pancreatitis (15 chronic, 4 acute).
- Occupational histories were taken to identify regular exposure to environmental factors.
- Patient symptoms were monitored following removal from or re-exposure to potential workplace toxins.
Main Results:
- In idiopathic pancreatitis patients, common exposures included diesel exhaust fumes, perchloroethylene, trichloroethylene, and paint solvents.
- In patients with alcohol-related pancreatitis who abstained from alcohol, similar occupational exposures were identified.
- Symptom resolution occurred in several patients upon removal from chemical exposure, with recurrence upon re-exposure.
Conclusions:
- Occupational exposure to aromatic or chlorinated hydrocarbons may be a significant factor in idiopathic pancreatitis.
- These exposures might also contribute to alcohol-related pancreatic disease.
- Further research into environmental triggers for pancreatitis is warranted.