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Use of convalescent plasma therapy in eight individuals with mild COVID-19

F Ji1, W Liu2, D-A Hao3

  • 1Department of Infectious Disease, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

New Microbes and New Infections
|November 18, 2020
PubMed

Insights

Convalescent plasma (CP) transfusion may improve symptoms and viral clearance in mild COVID-19 patients. However, CP might temporarily increase inflammation in some individuals and its effects are not permanent.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Hematology

Background:

  • Coronavirus disease 2019 (COVID-19) remains a global health concern.
  • Convalescent plasma (CP) transfusion is explored as a therapy for severe COVID-19, but clinical trial results are mixed.
  • Limited data exist on CP efficacy in patients with mild COVID-19.

Purpose of the Study:

  • To evaluate the clinical and virological effects of convalescent plasma transfusion in individuals with mild COVID-19.
  • To assess changes in laboratory markers and symptom resolution following CP therapy in mild COVID-19 cases.

Main Methods:

  • A case series involving eight individuals with mild COVID-19 who received at least one dose of CP.
  • Monitoring of clinical symptoms, lymphocyte counts, lactate dehydrogenase, creatine kinase, aspartate aminotransferase, and C-reactive protein.
  • Tracking the time to negative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid test post-transfusion.

Main Results:

  • All eight participants showed improvement in clinical symptoms after CP transfusion.
  • Trends indicated an increase in lymphocyte counts and decreases in certain enzymes (LDH, CK, AST).
  • A transient increase in C-reactive protein was observed in three patients; median time to SARS-CoV-2 negativity was 2.5 days.

Conclusions:

  • Convalescent plasma transfusion shows potential benefits for mild COVID-19, including symptom improvement and faster viral clearance.
  • CP may transiently enhance inflammatory responses in individuals with inadequate antiviral immunity.
  • The therapeutic effects of convalescent plasma are not sustained long-term.

Keywords:
Convalescent plasmacoronavirus disease 2019immunitysevere acute respiratory syndrome coronavirus 2treatment

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