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Updated: Nov 29, 2025

Measurements of Physiological Stress Responses in C. Elegans
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Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

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NRF2-dependent stress defense in tumor antioxidant control and immune evasion

José Pedro Friedmann Angeli1, Svenja Meierjohann2,3

  • 1Rudolf-Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany.

Pigment Cell & Melanoma Research
|November 18, 2020
PubMed

Insights

Nuclear factor erythroid 2-related factor 2 (NRF2) drives drug resistance and immune evasion in cancers like lung adenocarcinoma. This review explores NRF2

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of oxidative stress response.
  • Oncogenic activation of NRF2 is linked to drug resistance and immune evasion in cancers such as lung adenocarcinoma.
  • NRF2 can be activated through various mechanisms beyond KEAP1/NRF2 pathway mutations, including radiation and tumor microenvironment factors.

Purpose of the Study:

  • To review the multifaceted roles of NRF2 in melanoma.
  • To elucidate NRF2's involvement in modulating differentiation and suppressing anti-tumor immunity in melanoma.
  • To discuss the therapeutic implications of targeting NRF2 in melanoma.

Main Methods:

  • Literature review of studies on NRF2 function in cancer.
  • Analysis of NRF2's role in oxidative stress, metabolism, differentiation, and immune response.
  • Discussion of current and potential therapeutic strategies targeting NRF2.

Main Results:

  • Activated NRF2 protects tumors from damage and adapts their metabolism.
  • NRF2 plays a role in melanoma differentiation and suppression of anti-tumor immunity.
  • NRF2 activation contributes to drug resistance and immune evasion in various cancer types.

Conclusions:

  • NRF2 has complex roles in melanoma, including immune evasion and differentiation modulation.
  • Targeting NRF2 may offer novel therapeutic strategies for melanoma.
  • Understanding NRF2's function is crucial for developing effective cancer treatments.
Keywords:
KEAP1Nrf2immune evasionoxidative stress

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