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Vancomycin: a review.

J F Levine1

  • 1New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark.

The Medical Clinics of North America
|November 1, 1987
PubMed
Summary
This summary is machine-generated.

Vancomycin use is increasing due to rising infections and new medical technologies. Further research is needed on its tissue distribution, toxicity, and monitoring susceptibility patterns to ensure effective treatment.

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Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Clinical Pharmacy

Background:

  • Increased prevalence of serious methicillin-resistant staphylococcal infections.
  • Expanded use in patients undergoing hemodialysis and continuous ambulatory peritoneal dialysis (CAPD).
  • Growing application in conjunction with prosthetic devices and aggressive chemotherapy regimens.

Purpose of the Study:

  • To review past experiences and update current data on vancomycin.
  • To highlight the expanding indications for vancomycin therapy.
  • To identify areas requiring further investigation regarding vancomycin's clinical use.

Main Methods:

  • Literature review of past vancomycin experience.
  • Analysis of updated data on vancomycin usage and clinical challenges.

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  • Identification of emerging trends in vancomycin application.

    • Main Results:

    • Vancomycin indications have significantly increased.
    • New purified preparations of vancomycin are available.
    • Clinical scenarios necessitating vancomycin have become more common.

    Conclusions:

    • Further research is essential on vancomycin's distribution in body tissues and its toxicity.
    • Continuous surveillance of in vitro susceptibility patterns is crucial.
    • The expanding use of vancomycin necessitates ongoing evaluation of its efficacy and safety.