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Updated: Nov 29, 2025

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery

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Published on: August 6, 2019

Azide-Terminated RAFT Polymers for Biological Applications.

Ziwen Jiang^1,2, Huan He^1,3, Hongxu Liu¹

¹Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts.

Current Protocols in Chemical Biology

|November 18, 2020

Summary

This summary is machine-generated.

This study presents a method to add azide groups to Reversible Addition-Fragmentation chain-transfer (RAFT) polymers. These azide-terminated polymers enable click chemistry for bioconjugation, fluorophore labeling, and organelle targeting.

Keywords:

RAFT polymerization click reaction conjugation end-group modification labeling

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Area of Science:

Polymer Chemistry
Organic Synthesis
Bioconjugation Chemistry

Background:

Reversible Addition-Fragmentation chain-transfer (RAFT) polymerization is a versatile technique for synthetic polymer production.
RAFT polymers are utilized in diverse biomedical applications such as drug delivery, imaging, and tissue engineering.

Purpose of the Study:

To develop a synthetic route for introducing azide functionalities onto RAFT polymer chain ends.
To establish a platform for facile chemical and bioconjugation reactions using azide-terminated RAFT polymers.

Main Methods:

Synthesis of azide derivatives for chain transfer agents and radical initiators.
Installation of azide groups at either the alpha- or omega-chain end of RAFT polymers.
Utilizing click chemistry for conjugation of azide-terminated polymers with alkyne-containing molecules.

Main Results:

Successfully synthesized azide-terminated RAFT polymers.
Demonstrated the utility of these polymers in click reactions for bioconjugation.
Showcased applications in fluorophore labeling and enhancing organelle targeting capabilities.

Conclusions:

The developed methodology provides a broadly applicable scaffold for modifying RAFT polymers.
Azide-terminated RAFT polymers offer a powerful tool for advanced applications in chemical biology and materials science.