Related Experiment Video

Updated: Nov 29, 2025

Translating Ribosome Affinity Purification TRAP for RNA Isolation from Endothelial Cells In Vivo
08:53

Translating Ribosome Affinity Purification TRAP for RNA Isolation from Endothelial Cells In Vivo

Published on: May 25, 2019

12.2K

The role of CD36 in cardiovascular disease

Hongyang Shu1,2, Yizhong Peng3, Weijian Hang1,2

  • 1Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.

Cardiovascular Research
|November 19, 2020
PubMed

Insights

CD36, a receptor crucial for fatty acid uptake in the heart, is implicated in cardiovascular diseases. Modulating CD36 levels may offer a novel therapeutic strategy for conditions like diabetic cardiomyopathy and atherosclerosis.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Biochemistry

Background:

  • CD36 (scavenger receptor B2) is vital for long-chain fatty acid uptake in myocardial tissue.
  • Its maturation and transport involve post-translational modifications like phosphorylation and glycosylation.
  • CD36 expression varies in cardiovascular pathologies, being decreased in ischemia-reperfusion and pressure overload, but increased in diabetic cardiomyopathy and atherosclerosis.

Purpose of the Study:

  • To review the regulation and post-translational modifications of CD36.
  • To evaluate the role of CD36 in cardiovascular diseases.
  • To assess the potential of CD36 as a therapeutic target.

Main Methods:

  • Literature review of studies on CD36.
  • Analysis of CD36 expression patterns in various cardiovascular conditions.
  • Evaluation of experimental data on CD36 deficiency and overexpression in disease models.

Main Results:

  • CD36 deficiency ameliorates diabetic cardiomyopathy and atherosclerosis.
  • CD36 overexpression protects against ischemia-reperfusion injury.
  • These findings highlight CD36's significant association with cardiovascular disease progression.

Conclusions:

  • CD36 plays a critical role in cardiovascular pathophysiology.
  • Targeting CD36 presents a promising therapeutic avenue for cardiovascular diseases.
  • Further research into CD36 regulation and function is warranted.

Keywords:
Cardiac hypertrophyCD36Diabetic cardiomyopathyIschaemia–reperfusionPost-translational modification

More Related Videos

Ferric Chloride-induced Murine Thrombosis Models10:37

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

22.6K
Quantification of Atherosclerosis in Mice06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

39.5K

Related Concept Videos

Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
3.0K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
691
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
221
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
200
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
598
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
201