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Barbiturate derivatives for managing multifaceted oncogenic pathways: A mini review

Parteek Prasher1,2, Mousmee Sharma1,3, Samarth P Singh2

  • 1UGC Sponsored Centre for Advanced Studies, Department of Chemistry, Guru Nanak Dev University, Amritsar, India.

Drug Development Research
|November 19, 2020
PubMed

Insights

Barbiturates show anticancer potential by targeting multiple cancer pathways. Derivatives offer a hybrid approach to manage complex cancer progression and drug resistance.

Area of Science:

  • Oncology
  • Medicinal Chemistry

Background:

  • Metastasis involves complex, synchronized pathway dysregulation, challenging conventional anticancer therapies.
  • Drug resistance and pathway interplay exacerbate cancer complexity.

Purpose of the Study:

  • To collate the role of barbiturates and their derivatives in managing cancer-associated pathways.
  • To explore barbiturates as potential agents against complex cancer mechanisms.

Main Methods:

  • Review of literature on barbiturates and their derivatives in cancer research.
  • Analysis of barbiturate activity against key cancer pathways (e.g., MMPs, HDACs, Ras/MAPK).

Main Results:

  • Barbiturates demonstrate anticancer activity by attenuating critical metabolic and enzymatic pathways.
  • Derivatization and conjugation create hybrid molecules with enhanced profiles for pathway management.

Conclusions:

  • Barbiturates and their derivatives represent a promising strategy for targeting multiple cancer pathways.
  • These compounds offer a potential avenue for overcoming drug resistance and managing metastatic disease.
Keywords:
angiogenesisanticancerbarbituratesmetastasis

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