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Activation of Janus kinase signaling pathway in acne lesions

Sara Mohamed Awad1, Yasmin Mostafa Tawfik1, Mohamed Ahmed El-Mokhtar2

  • 1Department of Dermatology, Venereology and Andrology, Assiut University Hospital, Assiut, Egypt.

Dermatologic Therapy
|November 19, 2020
PubMed

Insights

Janus kinase (JAK) signaling is implicated in acne inflammation. JAK1 and JAK3 proteins are overexpressed in acne lesions, suggesting they may be therapeutic targets for acne vulgaris.

Area of Science:

  • Dermatology
  • Immunology
  • Molecular Biology

Background:

  • The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway is crucial in inflammatory skin conditions.
  • The specific role of JAKs in acne vulgaris pathogenesis remains largely unexplored.

Purpose of the Study:

  • To investigate the expression of JAK1, JAK2, and JAK3 proteins in acne vulgaris lesions.
  • To explore the potential involvement of JAK signaling in the development of acne.

Main Methods:

  • A case-control study involving 28 acne vulgaris patients and 20 healthy controls.
  • Analysis of JAK1/2/3 protein expression in skin biopsies using real-time quantitative polymerase chain reaction.
  • Acne severity assessment using the Global acne severity grading system (GAGS).

Main Results:

  • JAK1 and JAK3 proteins were significantly overexpressed in acne lesions compared to non-lesional skin and control skin.
  • No significant difference in JAK2 expression was observed between acne patients and controls.
  • JAK1 and JAK3 expression levels did not correlate with patient age, sex, disease duration, or severity (GAGS score).

Conclusions:

  • The findings suggest the activation of the JAK signaling pathway in acne lesions.
  • JAK1 and JAK3 may play a pivotal role in the inflammatory processes underlying acne vulgaris.
  • JAK1 and JAK3 represent potential novel therapeutic targets for acne treatment.
Keywords:
JAK inhibitorsJAK/STAT pathwayJanus kinasesacne vulgarisinflammation

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