Related Experiment Video
Updated: Nov 29, 2025
04:40
Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
15.7K
[ISCHEMIA trial : Is coronary CT angiography the new gatekeeper?]
M Moshage1,2, S Smolka3, S Achenbach3
1Medizinische Klinik 2 - Kardiologie und Angiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Deutschland. maximilian.moshage@uk-erlangen.de.
Der Radiologe
|November 19, 2020
Summary
For patients with coronary artery disease (CAD) and ischemia, revascularization did not improve outcomes compared to optimal medical therapy alone. Coronary computed tomography angiography (CTA) showed promise in diagnosing CAD.
Area of Science:
- Cardiology
- Medical Imaging
- Clinical Trials
Background:
- Coronary artery disease (CAD) management involves medical therapy versus revascularization.
- The ISCHEMIA trial investigated these strategies in patients with positive ischemia tests.
Purpose of the Study:
- To determine if routine revascularization improves clinical outcomes over optimal medical therapy alone in CAD patients with ischemia.
- To evaluate the role of coronary computed tomography angiography (CTA) in managing CAD.
Main Methods:
- Systematic comparison of medical therapy versus revascularization.
- Exclusion of left main stenosis using coronary CTA prior to randomization.
Main Results:
- Revascularization did not yield a prognostic benefit over optimal medical therapy.
- Coronary CTA demonstrated potential as a diagnostic tool for suspected CAD.
Conclusions:
- The hypothesis that revascularization improves outcomes was not confirmed.
- Coronary CTA shows promise as a diagnostic tool in suspected CAD.
- Future studies are needed to address new questions in cardiac imaging.
Keywords:
Acute coronary syndromesCoronary heart diseaseDiagnostic imagingRevascularisationStable coronary artery diseaseMore Related Videos
Related Concept Videos
01:28Imaging Studies for Cardiovascular System V: CT
154
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
154
01:30Acute Coronary Syndrome III: Diagnostic Studies
107
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
107
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
235
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
235
01:27Coronary Artery Disease V: Interprofessional Care
141
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
141
01:28Cardiac Catheterization I: Pre-Procedure Overview
615
Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
615
01:28Acute Coronary Syndrome IV: Interprofessional Care
111
IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
111