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[COVID-19 and asthma]
Revue Medicale De Liege
|November 19, 2020
Summary
Asthma patients generally face no increased risk from SARS-CoV-2 infection or severe outcomes. However, severe asthma cases with comorbidities may be at higher risk, while inhaled corticosteroids might offer protection.
Area of Science:
- Pulmonology
- Infectious Diseases
- Virology
Background:
- The SARS-CoV-2 pandemic raised concerns about increased hospitalizations for asthma exacerbations.
- Respiratory viruses are known triggers for asthma flare-ups.
Purpose of the Study:
- To investigate the association between asthma and SARS-CoV-2 infection severity.
- To evaluate the impact of asthma medications on COVID-19 outcomes.
Main Methods:
- Analysis of patient data regarding asthma status and COVID-19 infection.
- Assessment of the role of inhaled corticosteroids (ICS) and biological therapies.
Main Results:
- Asthma is not identified as a significant risk factor for SARS-CoV-2 infection or mortality.
- Inhaled corticosteroids (ICS) may decrease ACE2 receptor expression, potentially reducing infection risk.
- Severe asthmatics with comorbidities or on oral steroids/high-dose ICS showed increased mortality risk.
- Biological therapies targeting IgE or interleukin-5 did not appear to increase severe infection risk.
Conclusions:
- Most asthma patients do not face heightened risks from SARS-CoV-2.
- Severe asthma, particularly with comorbidities, warrants careful monitoring during the pandemic.
- Current asthma management strategies, including ICS, seem safe concerning COVID-19.
- Targeted biologicals for asthma do not elevate the risk of severe SARS-CoV-2 infection.
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