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A systematic review of microRNAs in patients with hypertrophic cardiomyopathy

Fernando Luís Scolari1, Lucas Simonetto Faganello2, Henrique Iahnke Garbin3

  • 1Division of Cardiology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil; Faculty of Medicine, Universidade Federal do Rio Grande do Sul, 2350 Ramiro Barcelos St, Porto Alegre, Rio Grande do Sul, Brazil.

International Journal of Cardiology
|November 19, 2020
PubMed
Abstract

Insights

MicroRNAs (miRNAs) are linked to hypertrophic cardiomyopathy (HCM). This review found 87 differentially expressed miRNAs, with miR-29a showing consistent links to HCM phenotypes and potential as a biomarker.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Genetics

Background:

  • Hypertrophic cardiomyopathy (HCM) is associated with various microRNAs (miRNAs).
  • Existing studies show methodological inconsistencies in assessing miRNA roles in HCM.
  • A systematic review is needed to consolidate findings on miRNAs in HCM.

Purpose of the Study:

  • To systematically review and synthesize existing research on microRNAs (miRNAs) associated with hypertrophic cardiomyopathy (HCM).
  • To identify commonly reported and differentially expressed miRNAs in HCM patients.
  • To explore the correlation between specific miRNAs and HCM phenotypes like hypertrophy and fibrosis.

Main Methods:

  • Systematic literature search using MeSH terms "Hypertrophic Cardiomyopathy" and "MicroRNA" and synonyms.
  • Searches conducted on Embase, Medline, and LILACS databases in April 2020.
  • Inclusion criteria: human studies with clear HCM diagnosis; independent data extraction and study evaluation.

Main Results:

  • 13 studies involving 329 patients met the criteria, identifying 87 differentially expressed miRNAs in HCM.
  • miR-21, miR-29a, and miR-133 were the most frequently reported miRNAs, predominantly upregulated.
  • miR-29a demonstrated consistent correlation with HCM phenotypes, specifically hypertrophy and fibrosis.

Conclusions:

  • A significant number of miRNAs are differentially expressed in hypertrophic cardiomyopathy patients.
  • miR-21, miR-29a, and miR-133 are key miRNAs implicated in HCM.
  • miR-29a shows promising potential as a reliable biomarker for HCM due to consistent phenotypic correlations.
Keywords:
CardiomyopathyEpigeneticHypertrophic cardiomyopathyLeft ventricular hypertrophyMyocardium fibrosismicroRNAs

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