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Proinflammatory microbial products as etiologic agents of inflammatory arthritis

R L Wilder1

  • 1Arthritis and Rheumatism Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, Bethesda, Maryland.

Rheumatic Diseases Clinics of North America
|August 1, 1987
PubMed

Insights

Proinflammatory microbial components like muramyl peptides may cause chronic inflammatory arthritis in humans. This review examines evidence linking these substances to human arthritis and their mechanisms in animal models.

Area of Science:

  • Microbiology
  • Immunology
  • Rheumatology

Background:

  • Chronic inflammatory arthritides are debilitating conditions with complex etiologies.
  • Microbial components, including muramyl peptides and endotoxins, are implicated in inflammation.

Purpose of the Study:

  • To review evidence supporting the role of proinflammatory microbial components in human chronic inflammatory arthritis.
  • To discuss the biological activities and mechanisms of these agents in inducing arthritis.

Main Methods:

  • Literature review of studies on microbial components and arthritis.
  • Analysis of data from experimental animal models of arthritis.
  • Evaluation of current research on human inflammatory diseases.

Main Results:

  • Muramyl peptides, peptidoglycans, and endotoxins exhibit proinflammatory activities.
  • These microbial components can induce various forms of arthritis in experimental animals.
  • Evidence linking these agents to human chronic inflammatory arthritis is under investigation.

Conclusions:

  • Proinflammatory microbial components are potential etiologic factors in human chronic inflammatory arthritis.
  • Further research is needed to definitively establish the role of these agents in human disease.

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