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[APUD system and neuroendocrine tumors ("apudomas")]
Arkhiv Patologii
|January 1, 1977
Summary
The APUD-system comprises neuroendocrine cells in various organs that produce amines or hormones. This review discusses tumors arising from these cells, detailing their characteristics.
Area of Science:
- Neuroendocrinology
- Cell Biology
- Oncology
Context:
- The diffuse neuroendocrine system, historically termed the amine precursor uptake and decarboxylation (APUD) system, involves cells scattered throughout diverse organs.
- These cells share a common characteristic: the ability to synthesize and secrete biogenic amines or peptide hormones.
Purpose:
- To present current concepts of the APUD-system.
- To discuss the development of tumors originating from APUD cells.
- To describe the morphological, histochemical, and clinical features of these neuroendocrine tumors.
Summary:
- The APUD system integrates neuroendocrine cells from various organs, defined by their capacity for amine precursor uptake, decarboxylation, and production of biogenic amines or polypeptide hormones.
- Tumorigenesis within this system is explored, encompassing the morphological, histochemical, and clinical manifestations of these neoplasms.
- This overview synthesizes current understanding of APUD cell biology and associated pathologies.
Impact:
- Provides a comprehensive overview of the APUD system for researchers and clinicians.
- Enhances understanding of neuroendocrine tumor development and characteristics.
- Facilitates improved diagnosis and management of APUD cell-related disorders.