Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

58.9K
Overview
58.9K
Inflammatory Response01:28

Inflammatory Response

15.3K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.3K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

6.6K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
6.6K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

14.6K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
14.6K
Bacterial Signaling01:30

Bacterial Signaling

39.0K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
39.0K
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

5.2K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
5.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuroinflammation and Mental Health in Multiple Sclerosis and Autoimmune Encephalitis: Bridging Biological Mechanisms and Psychosocial Factors.

Archives of internal medicine research·2026
Same author

Most Effective Interventions for Enhancing Neural Plasticity for Functional Recovery in Patients with Traumatic Brain Injury.

Journal of surgery and research·2026
Same author

Post-Pandemic Evaluation of Emergency Medicine Workforce Stability.

Archives of clinical and medical case reports·2026
Same author

Mohs Surgery vs. Wide Local Excision for Non-Melanoma Skin Cancer: Comparing Recurrence Rates, Economic Value, and Aesthetic Outcomes.

Journal of cancer science and clinical therapeutics·2026
Same author

Cost-efficient and Accurate Risk Assessment Instruments in Type 2 Diabetics with Greatest Risk for Cardiovascular Disease.

Cardiology and cardiovascular medicine·2026
Same author

Shifting Career Landscapes: Analyzing the Fall in Physician-Owned Practices.

Archives of clinical and medical case reports·2026
Same journal

Photobiomodulation Targets Mitochondrial Homeostasis for Diabetic Wound Healing.

Tissue engineering. Part B, Reviews·2026
Same journal

Nanotechnology-Driven Noninvasive and Targeted Therapies for Anaplastic Thyroid Carcinoma.

Tissue engineering. Part B, Reviews·2026
Same journal

From Restoration to Regeneration: A Review of 3D Printing Strategies in Digital Dentistry.

Tissue engineering. Part B, Reviews·2026
Same journal

Molecular Pathogenesis of and Regenerative Strategies for Osteonecrosis of the Femoral Head.

Tissue engineering. Part B, Reviews·2026
Same journal

Regenerative Potential of Platelet-Rich Plasma-Loaded Scaffolds in Endometrial Damage: A Meta-Analysis.

Tissue engineering. Part B, Reviews·2026
Same journal

Enhancing Round Window Membrane Permeability for Inner Ear Drug Delivery: A Systematic Review.

Tissue engineering. Part B, Reviews·2026
See all related articles

Related Experiment Video

Updated: Nov 29, 2025

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
07:51

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch

Published on: December 10, 2020

5.9K

Biomaterials-Driven Sterile Inflammation.

Henry Chen1, Devendra K Agrawal1, Finosh G Thankam1

  • 1Department of Translational Research, Western University of Health Sciences, Pomona, California, USA.

Tissue Engineering. Part B, Reviews
|November 20, 2020
PubMed
Summary
This summary is machine-generated.

Biomaterials for regenerative medicine can cause sterile inflammation, limiting their effectiveness. Understanding biomaterials-driven sterile inflammation (BSI) and its molecular triggers is crucial for improving tissue regeneration strategies.

Keywords:
DAMPsbiocompatibilitybiomaterialsimplant immunologysterile inflammation

More Related Videos

Polarization and Characterization of M1 and M2 Human Monocyte-Derived Macrophages on Implant Surfaces
08:37

Polarization and Characterization of M1 and M2 Human Monocyte-Derived Macrophages on Implant Surfaces

Published on: December 6, 2024

1.3K
Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

13.1K

Related Experiment Videos

Last Updated: Nov 29, 2025

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch
07:51

A Multi-Cue Bioreactor to Evaluate the Inflammatory and Regenerative Capacity of Biomaterials under Flow and Stretch

Published on: December 10, 2020

5.9K
Polarization and Characterization of M1 and M2 Human Monocyte-Derived Macrophages on Implant Surfaces
08:37

Polarization and Characterization of M1 and M2 Human Monocyte-Derived Macrophages on Implant Surfaces

Published on: December 6, 2024

1.3K
Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

13.1K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Immunology

Background:

  • Biocompatibility is key for regenerative medicine biomaterials, but underlying mechanisms are poorly understood.
  • Host responses to biomaterials include immune responses and sterile inflammation, impacting scaffold integration.
  • Long-term host-biomaterial interactions and their progression remain largely undescribed.

Purpose of the Study:

  • To explore the novel concept of biomaterials-driven sterile inflammation (BSI) in long-term biodegradable implants.
  • To elucidate potential explanations for the onset of BSI and associated damage-associated molecular patterns.
  • To advance strategies for improving biomaterial-host tissue integration in regenerative medicine.

Main Methods:

  • Literature review and conceptual analysis of host-biomaterial interactions.
  • Exploration of sterile inflammatory responses to biodegradable implants.
  • Discussion of damage-associated molecular patterns in the context of BSI.

Main Results:

  • Identified biomaterials-driven sterile inflammation (BSI) as a critical factor in long-term implant performance.
  • Proposed potential mechanisms and molecular triggers (damage-associated molecular patterns) for BSI.
  • Highlighted the limited understanding of long-term host-biomaterial relationships.

Conclusions:

  • Understanding BSI is essential for optimizing biomaterial design and application in regenerative medicine.
  • Elucidating BSI mechanisms can lead to improved biomaterial-host tissue integration.
  • This knowledge opens new translational pathways for tissue engineering and regenerative strategies.