Related Experiment Video

Updated: Nov 29, 2025

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.7K

Vitamin D/VDR in Acute Kidney Injury: A Potential Therapeutic Target

Siqing Jiang1, Lihua Huang2, Wei Zhang1

  • 1Department of Nephrology, Third Xiangya Hospital, Central South University, 138 Tongzipo Rd, Changsha, Hunan 410013, China.

Current Medicinal Chemistry
|November 20, 2020
PubMed

Insights

Vitamin D and its receptor (VDR) show therapeutic potential for acute kidney injury (AKI). Further clinical research is needed to confirm vitamin D/VDR agonists

Area of Science:

  • Nephrology
  • Endocrinology
  • Molecular Biology

Background:

  • Acute kidney injury (AKI) presents high mortality and poor prognosis despite current treatments.
  • Vitamin D and its receptor (VDR) are increasingly recognized for their role in kidney health and disease.
  • Vitamin D deficiency is linked to increased risk and severity in both clinical and experimental AKI.

Purpose of the Study:

  • To review current research on the role of vitamin D/VDR in AKI.
  • To explore the therapeutic potential of vitamin D and VDR modulation for AKI.
  • To identify areas for future clinical research and therapeutic development.

Main Methods:

  • Literature review of experimental and clinical studies.
  • Analysis of existing data on vitamin D and VDR in AKI models and patients.
  • Synthesis of findings regarding the mechanisms and clinical implications of vitamin D/VDR in AKI.

Main Results:

  • Accumulated evidence suggests vitamin D/VDR plays a protective role in AKI.
  • Vitamin D deficiency is a significant risk factor for AKI development and progression.
  • Vitamin D/VDR pathways represent a promising therapeutic target for AKI management.

Conclusions:

  • Vitamin D and VDR agonists hold potential as novel therapeutic strategies for AKI.
  • Further high-quality clinical trials are essential to validate efficacy and determine optimal administration.
  • Research is needed on appropriate dosage and delivery methods for vitamin D-based AKI therapies.
Keywords:
Vitamin DVitamin D receptoracute kidney injurydeficiencydosage.therapeutic target

More Related Videos

Intravascular Delivery of Biologics to the Rat Kidney07:29

Intravascular Delivery of Biologics to the Rat Kidney

Published on: September 1, 2016

7.9K
Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats06:38

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Published on: March 11, 2016

12.4K

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
159
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
588
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
149
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
325
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
488
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
217