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Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate

Jacynthe L Toulouse1,2,3, Genbin Shi4, Claudèle Lemay-St-Denis1,2,3

  • 1Département de biochimie, Université de Montréal, Montréal, Quebec H3T 1J4, Canada.

ACS Medicinal Chemistry Letters
|November 20, 2020
PubMed
Summary

New dihydrofolate reductases (DfrBs) confer trimethoprim resistance in microbes. Novel inhibitors targeting both DfrB and HPPK enzymes show promise for combating drug resistance.

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