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Related Concept Videos

Model Approaches for Pharmacokinetic Data: Compartment Models01:14

Model Approaches for Pharmacokinetic Data: Compartment Models

368
Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
Two primary types of compartment models are recognized: mammillary and catenary. The more...
368
One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance00:56

One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance

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Clearance is a key pharmacokinetic parameter that quantifies the volume of body fluid from which a drug is entirely removed within a specific time frame. It is crucial in assessing how a drug is eliminated from the body and has critical clinical applications.
In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...
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Clearance Models: Noncompartmental Models01:17

Clearance Models: Noncompartmental Models

147
Clearance is a pharmacokinetic parameter traditionally defined by compartment models, signifying the rate at which a drug is expelled from the body. However, a noncompartmental model offers an alternative method for assessing clearance, primarily employing empirical data obtained after administering a single drug dose.
The noncompartmental approach capitalizes on extensive sampling data, correlating the volume of distribution to systemic exposure and the administered dosage. This method enables...
147
Dosage Regimen Designs: Nomograms and Tabulations01:23

Dosage Regimen Designs: Nomograms and Tabulations

82
Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...
82
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

234
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
234
Methods of Documentation VI: Case Management Model01:15

Methods of Documentation VI: Case Management Model

738
The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic...
738

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A robust optimization model for tactical capacity planning in an outpatient setting.

Nazanin Aslani1, Onur Kuzgunkaya1, Navneet Vidyarthi2

  • 1Department of Mechanical, Industrial and Aerospace Engineering, Gina Cody School of Engineering and Computer Science, Concordia University, 1455 de Maisonneuve Blvd. W., Montréal, Québec, H3G 1M8, Canada.

Health Care Management Science
|November 20, 2020
PubMed
Summary

This study introduces a robust optimization model for tactical capacity planning in clinics. It ensures 100% appointment feasibility despite demand uncertainty, saving costs and identifying critical physician workload periods.

Keywords:
Access timeCardinality-constrained robust optimizationDemand uncertaintyOperations researchOutpatient clinicTactical capacity planning

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Area of Science:

  • Operations Research
  • Healthcare Management
  • Applied Mathematics

Background:

  • Tactical capacity planning is crucial for healthcare resource allocation, particularly physician time.
  • Uncertainty in appointment demand challenges precise matching of physician availability with patient requests.
  • Scarce resources like physician time necessitate robust planning strategies.

Purpose of the Study:

  • To develop a robust optimization model for tactical capacity planning in outpatient settings.
  • To ensure feasible allocation of physician resources against demand uncertainty.
  • To evaluate the model's performance and identify critical workload periods.

Main Methods:

  • Utilizing cardinality-constrained robust optimization for capacity planning.
  • Modeling outpatient clinics with first-visit and re-visit patients, including access time targets.
  • Experimentally evaluating the robust model under varying conservatism levels.

Main Results:

  • Guaranteed 100% feasibility of the tactical capacity plan across all demand scenarios.
  • Demonstrated cost savings by avoiding full conservatism while meeting demand.
  • Identified critical time periods of worst-case physician peak load.

Conclusions:

  • The robust optimization model provides a feasible and cost-effective solution for healthcare capacity planning under uncertainty.
  • The model aids decision-makers in understanding and mitigating physician workload peaks.
  • Translating data into uncertainty sets significantly impacts the conservatism of the planning solution.