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Related Experiment Video

Updated: Nov 29, 2025

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Liquid-Flowing Graphene Chip-Based High-Resolution Electron Microscopy.

Kunmo Koo1, Jungjae Park1, Sanghyeon Ji1

  • 1Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.

Advanced Materials (Deerfield Beach, Fla.)
|November 20, 2020
PubMed
Summary

This study introduces a novel liquid-flowing graphene chip TEM (LFGC-TEM) for high-resolution, in situ imaging. This advanced platform enables live imaging of biological phenomena with unprecedented detail.

Keywords:
atomic resolution imagingbiological imaging platformsgraphene liquid cellsliquid-phase transmission electron microscopyoperando electron microscopy

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Area of Science:

  • Electron Microscopy
  • Materials Science
  • Nanotechnology

Background:

  • Liquid-phase transmission electron microscopy (TEM) offers significant potential but faces challenges in achieving high-resolution and operando imaging.
  • Existing methods often struggle with maintaining sample integrity and resolution in liquid environments.

Purpose of the Study:

  • To develop a novel in situ imaging platform for liquid-phase TEM.
  • To overcome the limitations of current techniques in achieving high-resolution imaging of dynamic processes in liquid.

Main Methods:

  • Development of a liquid-flowing graphene chip TEM (LFGC-TEM) platform.
  • Integration of graphene viewing windows and a liquid exchange system.
  • Testing the robustness of graphene chips under high-pressure gradients and rapid liquid circulation.

Main Results:

  • LFGC-TEM achieves atomic resolution for colloidal nanoparticles.
  • Molecular-level information is obtained for unstained wet biomolecules and cells.
  • The platform demonstrates robustness comparable to conventional SiNx chips under demanding conditions.

Conclusions:

  • The LFGC-TEM platform provides a breakthrough for high-resolution, in situ liquid-phase electron microscopy.
  • This technology enables live imaging of biological phenomena, a capability not previously achieved.
  • The platform opens new avenues for studying dynamic processes in biology and materials science.