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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Tumor Genomic Testing: Identifying Characteristics Associated With Germline Risk for Developing Malignancy.

Suzanne M Mahon1

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Tumor genomic testing guides cancer treatment. Reviewing tumor reports and family history can identify families needing genetic counseling for hereditary cancer risk.

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Area of Science:

  • Oncology
  • Genomics
  • Cancer Genetics

Background:

  • Tumor genomic testing aids personalized cancer treatment selection.
  • Germline genomic testing impacts patient and family cancer prevention strategies.

Purpose of the Study:

  • To highlight the importance of integrating tumor genomic testing insights with family history.
  • To emphasize the identification and referral of families with potential hereditary cancer risk.

Main Methods:

  • Analysis of tumor genomic testing reports.
  • Review of patient family histories of malignancy.

Main Results:

  • Tumor genomic testing provides crucial data for treatment decisions.
  • Family history review is key to identifying hereditary cancer predispositions.

Conclusions:

  • Integrating tumor genomic testing and family history is vital for comprehensive cancer care.
  • This integrated approach facilitates genetic counseling and testing for at-risk families.