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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Invasive dermatophyte infection: A systematic review.

Ruojun Wang1,2,3, Chen Huang4, Yi Zhang1,2,3

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Invasive dermatophytosis is rare but serious, often linked to weakened immunity or genetic factors. Early treatment of superficial fungal infections is crucial for high-risk individuals to prevent severe outcomes.

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CARD9STAT3Trichophytoninvasive dermatophytosismicrosporumsystemic review

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Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Dermatophyte infections typically manifest as superficial cutaneous mycoses.
  • Invasive dermatophytosis, a rare deep-tissue infection, poses significant clinical challenges.

Purpose of the Study:

  • To systematically review all reported cases of invasive dermatophytosis over a 20-year period (2000-2020).
  • To identify predisposing factors, causative pathogens, clinical characteristics, and outcomes of invasive dermatophytosis.

Main Methods:

  • Systematic literature search of PubMed/Medline, EMBASE, and Web of Science databases.
  • Inclusion of 160 individual cases of invasive dermatophytosis reported between 2000 and 2020.
  • Analysis of patient demographics, predisposing factors, identified dermatophyte species, and treatment outcomes.

Main Results:

  • The most common predisposing factors included superficial dermatophytosis, solid organ transplantation, and immunosuppressant use.
  • Trichophyton rubrum was the predominant pathogen (53.1%).
  • Overall mortality was 7.9%, with significantly higher mortality (17.4%) in patients with gene mutations compared to those without (5.5%).

Conclusions:

  • Invasive dermatophytosis disproportionately affects immunocompromised individuals and those with specific gene mutations (e.g., CARD9, STAT3).
  • Preventive management of superficial tinea in high-risk populations is essential to avert invasive disease.
  • Gene-deficient patients often require long-term antifungal therapy for infection control.