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Related Experiment Videos

Delayed hypersensitivity responses in children after local cutaneous anesthesia.

B Björkstén1, B Jung, E B Tågsjö

  • 1Department of Pediatrics, University Hospital, Linköping, Sweden.

Acta Paediatrica Scandinavica
|November 1, 1987
PubMed
Summary

Cutaneous analgesia effectively reduced pain during delayed-type hypersensitivity (DTH) skin tests in children but did not affect DTH reactions. This suggests DTH testing can be simplified in immunized populations.

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Area of Science:

  • Immunology
  • Dermatology
  • Pediatrics

Background:

  • Delayed-type hypersensitivity (DTH) is a crucial immune response.
  • Assessing DTH reactions in children can be challenging due to pain.
  • Cutaneous analgesia aims to mitigate procedural discomfort.

Purpose of the Study:

  • To evaluate the impact of cutaneous analgesia on DTH reactions.
  • To determine the efficacy of lidocaine/prilocaine in reducing pain during DTH testing.
  • To assess the utility of specific antigens for DTH testing in school children.

Main Methods:

  • A lidocaine/prilocaine mixture was compared to a placebo for cutaneous analgesia.
  • DTH reactions were induced by skin injections and assessed after 48 hours.
  • Antigen testing included tetanus, mumps, tuberculin, and candida in 116 school children.

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Main Results:

  • Cutaneous analgesia significantly reduced pain (p < 0.001) without altering DTH reactions.
  • High positivity rates were observed for tetanus (98%) and mumps (82%) antigens.
  • Lower positivity rates were found for tuberculin (11%) and candida (62%) antigens.

Conclusions:

  • Cutaneous analgesia is a safe and effective method for pain reduction in pediatric DTH testing.
  • DTH testing in adequately immunized children can be streamlined by using fewer, highly positive antigens like tetanus and mumps.
  • Routine use of cutaneous analgesia is recommended for DTH testing in young children to improve compliance and reduce distress.