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Related Experiment Video

Updated: Nov 29, 2025

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

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Published on: August 16, 2020

Adipose Tissue Lipokines: Recent Progress and Future Directions.

Veronica L Li^1,2, Joon T Kim^1,2, Jonathan Z Long^3,2

¹Department of Pathology, Stanford University School of Medicine, Stanford, CA.

|November 21, 2020

Summary

Adipose tissue releases lipid signals called lipokines, which regulate glucose and lipid metabolism. These findings highlight lipokines as key endocrine factors in metabolic health.

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Area of Science:

Endocrinology
Metabolism
Adipose Tissue Biology

Background:

Adipose tissue functions beyond energy storage, acting as an endocrine organ.
Historically, research focused on polypeptide adipokines, neglecting lipid-based signaling molecules.
Emerging evidence identifies adipose-derived lipids, or lipokines, as crucial endocrine factors.

Purpose of the Study:

To review recent advancements in understanding adipose-secreted lipokines.
To elucidate the role of lipokines in regulating glucose and lipid metabolism.
To discuss future research directions and experimental limitations.

Main Methods:

Literature review of studies on adipose-derived lipokines.
Analysis of the connection between lipokines and intracellular fatty acid metabolism.
Discussion of experimental data and future research strategies.

Main Results:

Lipokines are blood-borne lipids secreted by adipose tissue.
These lipokines communicate adipocyte energy status to tissues like the liver, muscle, and pancreas.
Lipokines play a significant role in endocrine regulation of glucose and lipid metabolism.

Conclusions:

Adipose-secreted lipokines represent a distinct class of endocrine regulators.
Further research is needed to fully understand lipokine function and therapeutic potential.
Addressing current experimental limitations is crucial for advancing the field.