Current and emerging therapies for coeliac disease

Area of Science:

• Gastroenterology and Immunology
• Autoimmune Diseases
• Dietary Medicine

Background:

• Coeliac disease is a common enteropathy in genetically susceptible individuals, triggered by gluten ingestion.
• Current management relies on a lifelong gluten-free diet, which presents challenges like cost, restrictiveness, and patient adherence.
• Some patients exhibit inadequate response or incomplete mucosal healing despite dietary adherence, necessitating alternative treatments.

Purpose of the Study:

• To provide a comprehensive overview of emerging therapeutic strategies for coeliac disease.
• To summarize recent advancements in the development of novel coeliac disease treatments.
• To highlight potential future therapies targeting the pathogenetic pathways of coeliac disease.

Main Methods:

• Literature review of current and emerging coeliac disease treatments.
• Analysis of investigational therapies in various stages of clinical trials.
• Synthesis of information on tolerogenic and immunological approaches.

Main Results:

• Multiple novel therapeutic targets for coeliac disease have been identified.
• Various investigational therapies, including tolerogenic and immunological approaches, are in development.
• Several drug candidates have advanced to Phase II/III clinical trials.

Conclusions:

• The understanding of coeliac disease pathogenesis has paved the way for innovative treatment options.
• Investigational therapies hold promise for improving outcomes for patients with coeliac disease.
• Future treatments may offer alternatives or adjuncts to the gluten-free diet, improving disease control and quality of life.