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Updated: Nov 29, 2025

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[Pathophysiology of overactive bladder].

X Gamé1, V Phé2

  • 1Département d'urologie, transplantation rénale et andrologie, CHU de Rangueil, université Paul-Sabatier, TSA50032, 31059 Toulouse, France.

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|November 22, 2020
PubMed
Summary
This summary is machine-generated.

Overactive bladder syndrome involves complex pathophysiology, including detrusor muscle dysfunction, urothelial changes, neurological issues, and urinary microbiome alterations. These factors are often influenced by aging and other health conditions.

Keywords:
Hyperactivité vésicaleIncontinenceOveractive bladderPathophysiologyPhysiopathologieReviewRevue

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Area of Science:

  • Urology
  • Pathophysiology

Background:

  • Overactive bladder syndrome (OAB) pathophysiology understanding has significantly advanced.
  • Current knowledge synthesis is crucial for understanding OAB.

Purpose of the Study:

  • To review and synthesize current knowledge on overactive bladder syndrome pathophysiology.
  • To provide an updated overview of OAB mechanisms.

Main Methods:

  • Systematic literature review conducted in February 2020.
  • Databases searched include Pubmed, Embase, and Google Scholar.
  • Keywords used were "overactive bladder" and "pathophysiology".

Main Results:

  • Four key pathophysiological mechanisms identified: detrusor muscle dysfunction, urothelial/sub-urothelial origin, neurological origin, and urinary microbiome changes.
  • These mechanisms are exacerbated by clinical conditions like aging, ischemia, metabolic syndrome, menopause, and abdominopelvic dysfunction.

Conclusions:

  • Overactive bladder syndrome pathophysiology is intricate.
  • Multiple, often associated, mechanisms contribute to OAB development.