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Updated: Nov 29, 2025
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Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
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[First-line treatment for non-neurogenic overactive bladder]
1Département d'urologie, transplantation rénale et andrologie, CHU Rangueil, université Paul-Sabatier, TSA50032, 31059 Toulouse, France.
Summary
First-line treatments for overactive bladder (OAB), including behavioral therapies, lifestyle changes, and medications, are effective. These interventions, when used alone or combined, offer proven benefits for managing OAB symptoms.
Area of Science:
- Urology
- Gynecology
- Geriatrics
Background:
- Overactive bladder (OAB) significantly impacts quality of life.
- Current knowledge on first-line OAB treatments requires synthesis.
Purpose of the Study:
- To systematically review and synthesize evidence on first-line treatments for overactive bladder (OAB).
Main Methods:
- Systematic literature review conducted in June 2020.
- Databases searched included PubMed, Embase, and Google Scholar.
Main Results:
- Behavioral treatments (bladder training, timed voiding) and lifestyle modifications (fluid intake, diet, weight management) are foundational.
- Pelvic floor muscle training (manual, electrostimulation, biofeedback) demonstrates effectiveness.
- Pharmacological options include oral anticholinergics and beta-3-agonists, with efficacy superior to placebo; local hormone therapy benefits menopausal women.
- Treatment combinations may be necessary upon monotherapy failure.
Conclusions:
- Prospective controlled studies confirm the efficacy of first-line OAB treatments.
- Individualized or combination therapeutic approaches are recommended for OAB management.
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