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Updated: Nov 29, 2025

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[Treatment for refractory non-neurogenic overactive bladder].

X Gamé1, V Phé2

  • 1Département d'urologie, transplantation rénale et andrologie, université Paul Sabatier, CHU Rangueil, TSA50032, 31059 Toulouse, France.

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|November 22, 2020
PubMed
Summary

Current treatments for refractory overactive bladder (OAB) include nerve stimulation and botulinum toxin A injections. These effective conservative OAB therapies are now preferred over surgical options.

Keywords:
Botulinum toxinHyperactivité vésicaleNeuromodulationOveractive bladderRefractoryRéfractaireToxine botuliqueTraitementTreatment

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Area of Science:

  • Urology
  • Nephrology

Background:

  • Synthesizes current knowledge on refractory overactive bladder (OAB) treatments.
  • Addresses the need for effective management strategies for OAB.

Purpose of the Study:

  • To review and synthesize current treatment options for refractory overactive bladder.
  • To evaluate the efficacy of existing and emerging therapies for OAB.

Main Methods:

  • Systematic literature review conducted in July 2020.
  • Databases searched include PubMed, Embase, and Google Scholar.

Main Results:

  • Current refractory overactive bladder treatments include percutaneous or transcutaneous tibial nerve stimulation, sacral neuromodulation, and botulinum toxin A detrusor injections.
  • These conservative treatments have largely replaced surgical interventions like supratrigonal cystectomy with augmentation cystoplasty.
  • Novel treatments are under investigation and available within clinical research protocols.

Conclusions:

  • Conservative treatments for refractory overactive bladder demonstrate significant effectiveness.
  • Further research and development may expand future treatment options for OAB.