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Updated: Nov 29, 2025
Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
Published on: May 24, 2021
Measuring Myocardial Energetics with Cardiovascular Magnetic Resonance Spectroscopy
Joevin Sourdon1, Sabra C Lewsey2, Michael Schär3
1Aix-Marseille Université, CNRS, CRMBM, Faculté de Médecine, 27 BVD Jean Moulin, Marseille 13005, France; Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Abstract:
The heart has the highest energy demands per gram of any organ in the body and energy metabolism fuels normal contractile function. Metabolic inflexibility and impairment of myocardial energetics occur with several common cardiac diseases, including ischemia and heart failure. This review explores several decades of innovation in cardiac magnetic resonance spectroscopy modalities and their use to noninvasively identify and quantify metabolic derangements in the normal, failing, and diseased heart. The implications of this noninvasive modality for predicting significant clinical outcomes and guiding future investigation and therapies to improve patient care are discussed.
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