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Updated: Nov 29, 2025

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

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Urgent therapeutic plasma exchange

Samir Saheb1, Antonio Gallo1

  • 1Unité d'hémobiothérapie, APHP, Sorbonne Université, Hôpital De La Pitié-Salpêtrière, Paris, France.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|November 22, 2020
PubMed

Therapeutic plasma exchange (TPE) is a well-established therapeutic procedure commonly used in many disorders of autoimmune etiology. The beneficial effects of TPE occur through the removal of pathognomonic inflammatory mediators; including autoantibodies, complement components, and cytokines. The use of TPE in the emergency setting is limited to a few indications. In this chapter, we focus on four conditions that we are most frequently faced with in the urgency setting: neuromyelitis optica-spectrum disorders, solid organ transplantation, and two metabolic conditions such as major hypertriglyceridemia and hyperthyroidism. We discuss the clinical setting defining the urgent character of TPE, the timing of treatment onset, the therapeutic pattern of TPE and the level of evidence currently available for each condition.

Keywords:
Plasma exchangeapheresisemergencyhypertrhyroidismhypertriglyceridemianeuromyelitis optica spectrum disordersorgan transplantation

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