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LINC00473: A novel oncogenic long noncoding RNA in human cancers
Lingfeng Li1,2,3,4,5, Xu Zhang1,2,3,4,5, Nian Liu1,2,3,4,5
1The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Abstract:
Long noncoding RNAs (lncRNAs) have been found to play essential roles in the occurrence and development of multiple human cancers. Accumulating evidence has shown that LINC00473, an oncogenic lncRNA, is upregulated in various human malignancies and related to poor clinical outcomes. Besides, LINC00473 overexpression can promote cell proliferation, migration, and invasion through multiple potential mechanisms, indicating that it may serve as a novel prognostic biomarker and therapeutic target for human cancers. Here, we reviewed the biological functions, molecular mechanisms, and clinical implications of LINC00473 in human cancers.
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