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Updated: Nov 29, 2025

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Published on: May 11, 2015
Pulmonary Arterial Hypertension in Pregnancy
Wenners Ballard1, Brittany Dixon2, Colleen A McEvoy3
1Division of Hospital Medicine, Department of Medicine, Washington University School of Medicine, 4523 Clayton Avenue, CB 8058, St Louis, MO 63110, USA.
Abstract:
Pulmonary arterial hypertension is a rare disease that predominantly affects women. The pathophysiology of the disease is complex, with both genetic and hormonal influences. Pregnancy causes significant physiologic changes that may not be well tolerated with underlying pulmonary arterial hypertension, in particular leading to volume overload and increased pulmonary pressures. A multidisciplinary approach and careful monitoring are essential for appropriate management of pulmonary arterial hypertension during pregnancy. Nonetheless, outcomes are still poor, and pregnancy is considered a contraindication in patients with pulmonary arterial hypertension.
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