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Hypertrophic Cardiomyopathy in Pregnancy

Sara Saberi1

  • 1Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan School of Medicine, 1500 East Medical Center Drive, CVC Suite 2364, Ann Arbor, MI 48109-5853, USA.

Cardiology Clinics
|November 23, 2020
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) in women of childbearing age generally has favorable maternal and fetal outcomes. Genetic counseling and pre-pregnancy risk assessment are crucial for optimal management and monitoring during pregnancy.

Area of Science:

  • Cardiology
  • Genetics
  • Reproductive Medicine

Background:

  • Hypertrophic cardiomyopathy (HCM) is a primary genetic heart condition with significant heterogeneity.
  • Increasingly diagnosed in women of reproductive age through advanced screening methods.

Purpose of the Study:

  • To evaluate maternal and fetal outcomes in women with HCM during pregnancy.
  • To outline recommended clinical management and risk stratification strategies.

Main Methods:

  • Review of clinical data and outcomes for pregnant women with HCM.
  • Emphasis on echocardiography, genetic screening, and clinical evaluations throughout gestation.

Main Results:

  • Maternal and fetal outcomes for women with HCM are generally favorable.
  • Most women experience moderate morbidity, requiring trimester evaluations and vaginal delivery.
  • Symptomatic women or those with significant left ventricular outflow obstruction/arrhythmias face higher risks.

Conclusions:

  • Pre-pregnancy evaluation and risk assessment are essential for managing HCM in pregnancy.
  • Regular monitoring, including echocardiography, is vital, with more frequent assessments for high-risk individuals.
  • Genetic counseling is recommended for women with HCM planning pregnancy.

Keywords:
Hypertrophic cardiomyopathyPre-pregnancy counselingPregnancy

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