Related Experiment Video
Updated: Nov 29, 2025
A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
Published on: April 6, 2016
Scanning Electron Microscopy of Subclinical Gefitinib-Induced Hair Changes
Hiram Larangeira de Almeida1,2, Debora Sarzi Sartori2, Antônia Larangeira de Almeida3
1Department of Dermatology, Catholic and Federal University of Pelotas, Rio Grande, Brazil.
Gefitinib, an epidermal growth factor receptor inhibitor, can cause subclinical hair changes like surface grooving. These subtle hair shaft alterations were detected via scanning electron microscopy, even without patient-reported symptoms.
Area of Science:
- Dermatology
- Oncology
- Pharmacology
Background:
- Epidermal growth factor receptor (EGFR) inhibitors are used to treat cancers like lung carcinoma.
- These inhibitors can cause various cutaneous side effects, including hair changes in 10%-20% of patients.
- Previous studies described ultrastructural hair changes (acquired pili torti et canaliculi) induced by erlotinib.
More Related Videos
06:41A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
Published on: March 9, 2015
06:51Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018