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A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
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Lipoprotein(a) and Familial Hypercholesterolemia: A Short Review Including the Laboratory Viewpoint

Masato Hamasaki1, Kazuhiko Kotani1

  • 1Division of Community and Family Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-City, Tochigi 329-0498, Japan.

Cardiology Research
|November 23, 2020
PubMed

Insights

Lipoprotein(a) (Lp(a)) significantly elevates cardiovascular disease (CVD) risk in familial hypercholesterolemia (FH) patients. Managing Lp(a) is crucial, as it can affect LDL-C measurements and FH diagnosis.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Chemistry
  • Genetics

Background:

  • Lipoprotein(a) (Lp(a)) and low-density lipoprotein cholesterol (LDL-C) are established risk factors for cardiovascular disease (CVD).
  • Familial hypercholesterolemia (FH) is characterized by elevated LDL-C, conferring a substantial CVD risk.
  • Elevated Lp(a) levels further exacerbate CVD risk in individuals with FH.

Purpose of the Study:

  • To review the role and measurement challenges of Lp(a) in patients with FH.
  • To discuss the implications of Lp(a) on LDL-C measurement and FH classification.
  • To highlight the importance of Lp(a) management in FH patients.

Main Methods:

  • Literature review focusing on Lp(a) and FH.
  • Analysis of Lp(a) measurement methodologies.
  • Discussion of clinical management strategies for Lp(a) in FH.

Main Results:

  • Lp(a) is an independent risk factor for CVD, particularly in FH.
  • Lp(a)-cholesterol (Lp(a)-C) can contribute to measured LDL-C, potentially leading to misclassification of FH.
  • Effective management of Lp(a) is essential for optimizing CVD risk reduction in FH.

Conclusions:

  • Accurate measurement and management of Lp(a) are critical in FH patients.
  • Addressing Lp(a) may improve the accuracy of FH diagnosis and treatment monitoring.
  • Further research into Lp(a) lowering therapies in FH is warranted.

Keywords:
Apoprotein(a)Cardiovascular riskDiagnosisLp(a)-CTherapeutic strategy

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