Bupropion-Induced Severe Leukocytosis
Taranjeet S Jolly1, Jatinder Singh2, Raman Baweja2
1Psychiatry and Behavioral Sciences, Penn State Health Milton S. Hershey Medical Center, Hershey, USA.
Cureus
|November 23, 2020
Summary
Bupropion overdose can cause significant leukocytosis, a rare hematological side effect. This case highlights the importance of monitoring blood counts in patients with bupropion toxicity.
Area of Science:
- Pharmacology
- Hematology
- Toxicology
Background:
- Bupropion hydrochloride is a widely prescribed norepinephrine-dopamine reuptake inhibitor.
- It is approved for treating depression and aiding smoking cessation.
- While common side effects include cardiovascular and hematological changes, severe hematological reactions are infrequent.
Observation:
- A case report details a 47-year-old female patient.
- The patient presented following an overdose of bupropion hydrochloride.
- Significant leukocytosis was observed in the patient's blood work.
Findings:
- The patient exhibited marked leukocytosis (elevated white blood cell count).
- This hematological finding is a rare side effect of bupropion, particularly in overdose scenarios.
- The leukocytosis developed subsequent to the bupropion overdose.
Implications:
- This case underscores the potential for bupropion overdose to induce significant hematological abnormalities.
- It suggests the need for vigilant monitoring of complete blood counts in cases of bupropion toxicity.
- Further research into bupropion-induced hematological effects, especially in overdose, may be warranted.
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