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Ribosomal Protein L10: From Function to Dysfunction
Daniela Pollutri1,2, Marianna Penzo1,2
1Department of Experimental, Diagnostic and Specialty Medicine Alma Mater Studiorum University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Cells
|November 24, 2020
Summary
Ribosomal protein L10 (RPL10) is crucial for ribosome function and biogenesis. This review explores RPL10
Area of Science:
- Molecular Biology
- Cell Biology
- Genetics
Background:
- Eukaryotic cytoplasmic ribosomes are essential for protein synthesis, composed of ribosomal RNAs (rRNAs) and ribosomal proteins (RPs).
- The ribosomal protein L10 gene (RPL10) is a component of the large ribosomal subunit.
- Previous research highlights RPL10's involvement in ribosome biogenesis and function.
Purpose of the Study:
- To review the literature on the role of RPL10 in physiological and pathological processes.
- To provide an overview of RPL10's function in inherited diseases and cancer.
Main Methods:
- Literature review of studies on yeast and human models.
- Analysis of existing research on RPL10's involvement in cellular processes.
Main Results:
- RPL10 is integral to the large ribosomal subunit.
- RPL10 plays a significant role in the late stages of ribosome biogenesis.
- RPL10 is implicated in ribosome function.
Conclusions:
- RPL10 is a key player in both normal cellular functions and disease states.
- Understanding RPL10's role is vital for research into inherited diseases and cancer.
- Further investigation into RPL10's mechanisms is warranted.
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